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June 7, 2000

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Hopkins to Break Ground For New Research Building

—to house McKusick-Nathans Institute for Genetic Medicine

Groundbreaking occurs on June 12 for construction of a 10-story, $140 million research building at Johns Hopkins' East Baltimore campus that's a concrete-and-brick metaphor for today's biomedical science.

The building, housing the McKusick-Nathans Institute for Genetic Medicine, other School of Medicine laboratories and a state-of-the-art mouse facility, becomes part of an approximately $324 million investment in research infrastructure on the medical campus.* It's slated to open early in 2004.

The State of Maryland is providing $23.8 million for the new structure.

The building's early stages, including design approval, have moved with unprecedented speed, reflecting Hopkins'determination to respond quickly as the scientific spotlight shifts to new areas of medical research and the NIH doubles its research budget.

The School of Medicine currently receives more NIH funding than any other medical school. "To maintain this position, we need more space for our brilliant scientists," says Edward D. Miller, M.D., dean of the medical faculty and CEO of Johns Hopkins Medicine.

Because many of the changes to come in biomedicine will be driven by current discoveries from the Human Genome Project, the McKusick-Nathans Institute for Genetic Medicine will be a key program. Institute scientists will study genes that trigger disease directly, as well as genes that make people more disease-susceptible. The scientists also will study how genes influence medical treatment.

The Institute is named for two Hopkins pioneers in genetics research, Lasker Award-winner Victor McKusick, M.D., University Professor of Medical Genetics, and Nobel laureate Daniel Nathans, who died early this year.

The new research labs also will reflect the blurring of scientific boundaries that marks biomedicine. Labs probably won't be arranged traditionally by department, planners say. "We want instead to bring a new cohesion to research by arranging the labs according to scientific problems," says Chi Dang, M.D., Ph.D., Vice Dean for Research. For example, labs of biologists studying genes that control embryo development might be clustered with those of researchers whose animal models for Down syndrome over-express those genes. Researchers exploring how the genes relate to mouse behavior might be in the cluster, as well as biochemists trying to tease out pathways in the brain that the genes activate.

Described by Miller as "the new gateway to the School of Medicine and another step in our continuing effort to revitalize this part of the city," the building will occupy a wedge-shaped lot bordering North Broadway and Madison Street. A spokesperson for Payette Associates of Boston, the architects, cites 380,000 gross square feet as the probable size.

Most important for researchers in the new building, as well as those throughout Hopkins, will be the easy availablity of "core facilities" — centers that offer often-costly cutting-edge technology or perform highly skilled techniques out of reach for individual labs. The building will house a DNA array center with the ability to tell which genes are expressed in individual cells and help pinpoint disease genes.

Another core facility will allow scientists to follow molecules step-by-step through small animals' biochemical pathways in real time. This facility aims to use molecular tracers and PET scanners with new precision.

A large state-of-the art "mouse house" in the building will foster the rapid creation of animal models of human disease. A combination of layout and robotics will greatly reduce stressful mouse/human contact under the most hygienic of conditions.

Expected to attend the groundbreaking ceremony are: Dr. McKusick, 7th District Congressman Elijah Cummings; Georges Benjamin, Secretary for Health and Mental Hygiene of the State of Maryland; U.S. Senator Paul Sarbanes; Michael Bloomberg, chairman of The Johns Hopkins University Board of Trustees and chairman of Bloomberg, L.P., as well as other state delegates and senators and Hopkins leaders.

*This initiative includes the new Bunting-Blaustein Cancer Research Building and clinical research areas of the new Harry and Jeanette Weinberg Comprehensive Cancer Center.

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