December 6,1994
Media Contact:Gary Stephenson
Phone: (410) 955-5384

"Dr. Kevorkian doesn't seem to be required to prove his point that it is the function of doctors to help people die--which is a point that flies in the face of the nature of medicine as it has been practiced since the Hippocratic oath." --Paul R. McHugh, M.D.

A study conducted by two researchers from the University of Southampton in England concludes that patients who suffer from a variety of chronic, debilitating, painful or even terminal medical conditions are no more likely to commit suicide than are members of the general population. However, mental disorders associated with other major diseases do lead to a heightened risk of suicide, they say.

The findings, based on an analysis of 235 studies of suicide published in the medical literature between 1966 and 1992, show that suicide rates are about the same as in the population as a whole for patients suffering from two dozen diseases or conditions. These include ALS (Lou Gehrig's disease), prostate or cervical cancer, non-Hodgkins lymphoma, diabetes, obesity, heart pacemakers, rheumatic diseases including rheumatoid arthritis, and viral hepatitis.

Suicide rates are significantly elevated, however, for persons suffering from AIDS (where the risk is nearly seven times that of the general population), Huntington disease (where the risk triples), systemic lupus erythematosus, many types of cancer, multiple sclerosis, spinal cord injury, peptic ulcers, and kidney problems requiring dialysis, report E. Clare Harris, M.Sc., and Brian M.Barraclough, M.D., in the November 1994 issue of the journal Medicine.

In an accompanying commentary, the director of psychiatry at The Johns Hopkins Medical Institutions questions whether the current interest in assisted suicide" may not lead seriously ill patients to leap to "dangerous and despairing assumptions that, if directly and traditionally combated, would wither."

The difference in suicide rates that is documented in the Harris and Barraclough study can be accounted for by the presence of major depression, which is a known consequence of many illnesses and which can be treated successfully, Paul R. McHugh, M.D., writes in his commentary.

"Major depression encourages suicide in patients not only by lowering mood but also by promoting in the patient the view that his life is hopeless; that he, himself, is worthless; and that his future is appalling," he writes. "These attitudes, like the depressed mood itself, are symptoms of disease and are reversed by pharmacologic and physical treatments."

In an interview, he added: "Rather than help their patients commit suicide, doctors should be alert for signs of major depression and should treat their patients aggressively. People want to live. They want to be treated by doctors who fight their fear and suffering, not by doctors who say their life is over."

He continued, referring to the current controversy over Dr. Jack Kevorkian and the suicides of seriously ill patients that he has aided in Michigan: "Dr. Kevorkian doesn't seem to be required to prove his point that it is the function of doctors to help people die--which is a point that flies in the face of the nature of medicine as it has been practiced since the Hippocratic oath."

On the bright side, the literature survey found that suicide rates fall significantly for women during pregnancy and the first year following delivery. A study in England and Wales found an eightfold decreased risk of suicide for women in this category, while an American study found a threefold decrease.

In his commentary, McHugh asks whether patients will not become more likely to take their own lives when doctors become more willing to help them do so.

"'Assisting' suicidal people will alter the links between suicide and medical afflictions," writes McHugh. "The practice should eventually be appraised with that in mind. For example, will conditions that never increased a patient's suicide risk begin to do so in Utrecht [The Netherlands] and Grand Rapids [Michigan]? Will more women choose a premature death through suicide when their doctors are ready, indeed eager, to provide it? Such appraisals will test whether 'assisted' patients are being helped or spurred to relinquish their lives."

Harris and Barraclough conclude that their examination of 63 medical disorders shows that those illnesses with a heightened risk of suicide are also those that have known associations with mental disorders or substance abuse. "This finding strengthens the evidence that mental disorders are the most important disease element in suicide," they write.

Medicine is edited by Victor McKusick, M.D., of Johns Hopkins and published by Williams & Wilkins in Baltimore. Johns Hopkins Medical Institutions' news releases can be accessed on-line through CompuServe. Look in the SciNews-MedNews library of Jforum under file extension "JHM."

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